Endocrine Abstracts

Background: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diseases starting with pathological accumulation of intrahepatocellular triglyceride (TG) (i.e. steatosis), which can progress to steatohepatitis (NASH) and cirrhosis. Insulin resistance is often associated with the development of steatosis and disease progression however, the underlying mechanisms for this are poorly defined. A major challenge in modelling human NAFLD disease progression is the la...

Background: Fasting hyperglycaemia and hypertriglyceridemia are characteristic of insulin resistance (IR), type 2 diabetes, and non-alcoholic fatty liver disease, but the underlying mechanisms remain unclear. Rodent work has suggested this is due to selective hepatic IR; defined by increased hepatic gluconeogenesis (GNG) and de novo lipogenesis (DNL). The aim of this study was to determine if signatures of selective hepatic IR were associated with hyp...